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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 25.76
Human Site: Y1456 Identified Species: 51.52
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 Y1456 S H S K S P A Y T P Q N L D S
Chimpanzee Pan troglodytes XP_001172395 1581 168474 Y1456 S H S K S P A Y T P Q N L D S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 Y1458 S H S K S P A Y T P Q N L D S
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 Y1458 S H S K S P A Y T P Q N V D S
Rat Rattus norvegicus NP_001127833 1567 166392 Y1442 S H S K S P A Y T P Q N V D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589 G326 Q L F D T H P G Q Q H C Y F L
Chicken Gallus gallus XP_418125 1594 169410 Y1467 S H S K S P A Y T P Q N I D S
Frog Xenopus laevis Q6INP8 1570 165663 P1447 S P S H N K S P A Y T P Q A L
Zebra Danio Brachydanio rerio XP_700209 1694 176982 G1514 Q K P G E G S G D G G I R S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 G1379 S M E G F I K G L H N K F Q I
Honey Bee Apis mellifera XP_395879 1811 193227 S1682 Q P Q Q V P S S G G S S S S S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 S1902 S P T G K S I S I K Q S K P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 0 93.3 13.3 0 N.A. 6.6 13.3 N.A. 20
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 100 26.6 6.6 N.A. 6.6 33.3 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 50 0 9 0 0 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 9 0 0 0 0 50 0 % D
% Glu: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 9 0 9 0 0 0 0 0 0 0 9 9 0 % F
% Gly: 0 0 0 25 0 9 0 25 9 17 9 0 0 0 0 % G
% His: 0 50 0 9 0 9 0 0 0 9 9 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 9 0 9 0 0 9 9 0 9 % I
% Lys: 0 9 0 50 9 9 9 0 0 9 0 9 9 0 0 % K
% Leu: 0 9 0 0 0 0 0 0 9 0 0 0 25 0 17 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 0 0 9 50 0 0 0 % N
% Pro: 0 25 9 0 0 59 9 9 0 50 0 9 0 9 0 % P
% Gln: 25 0 9 9 0 0 0 0 9 9 59 0 9 9 9 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % R
% Ser: 75 0 59 0 50 9 25 17 0 0 9 17 9 17 67 % S
% Thr: 0 0 9 0 9 0 0 0 50 0 9 0 0 0 0 % T
% Val: 0 0 0 0 9 0 0 0 0 0 0 0 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 50 0 9 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _